The ATR–ATRIP kinase complex safeguards genome integrity by coordinating cellular responses to DNA damage and replication stress. Two recent cryo-EM studies resolve the structural basis of ATR–ATRIP ...

Before a cell divides, its DNA is replicated so that each daughter cell inherits the same genetic information. The two copies, known as "sister chromatids," are held together by a ring-shaped protein ...

DNA replication in eukaryotic cells is a highly coordinated, multi-step process that ensures precise duplication of the genome prior to cell division. In late mitosis and early G1 phase, the Origin ...

A new discovery by researchers at the RIKEN Center for Biosystems Dynamics (BDR) in Japan upends decades of assumptions regarding DNA replication. Led by Ichiro Hiratani and colleagues, the ...

At the scale of individual cells, the human body is constantly in motion. Every second, millions of cells divide, particularly in tissues such as the bone marrow, intestine and skin; neurons and heart ...

The Okazaki Fragments That Solved the Mystery of DNA Replication1. The Mystery That Could Not Be Solved by the Discovery of ...

A protein that is involved in determining which enzymes cut or unwind DNA during the replication process has been identified. A protein that is involved in determining which enzymes cut or unwind DNA ...

Every embryo begins with a race against time. Primordial germ cells, the rapidly dividing precursors that ultimately give rise to eggs and sperm, must copy and safeguard their entire genome over and ...

For the first time, scientists have witnessed the very moment DNA begins to unravel, revealing a necessary molecular event for DNA to be the molecule that codes all life. A new study from King ...

King Abdullah University of Science & Technology (KAUST)Mar 19 2025 Reviewed For the first time, scientists have witnessed the very moment DNA begins to unravel, revealing a necessary molecular event ...

If parent cells and their daughter cells are to share a stable identity, parent cells must divide—and replicate their DNA—while ensuring that their histones are distributed properly to their daughter ...

It has been discovered that there are multiple types of DNA sites prone to breakage, beyond those previously known. This was announced by RIKEN, Kobe University, and JST. By examining cells one by one ...