Cell death in dementia has long posed a frustrating problem. Toxic proteins pile up inside neurons in Alzheimer’s disease and ...

Neuronal pathways originating from the orbitofrontal cortex (OFC) of the brain participate in different adaptive behaviors, but which pathways are used for distinct adaptive strategies remains unclear ...

While early in life, the accumulation of iron appears to have little effect on neuron function, later in life, it can ...

During brain development, neurons can regulate their movement until they reach their final destination thanks to a "molecular switch" involving the protein Teneurin 4 (Ten4). This protein can guide ...

In a new study published in Science Signaling titled, “Restoration of striatal neuroprotective pathways by kinase inhibitor treatment of Parkinson’s linked-LRRK2 mutant mice,” researchers from ...

Lysosomes regulate cellular metabolism to maintain cell survival, but the mechanisms whereby they determine neuronal cell fate after acute metabolic stress are unknown. Neuron-enriched lysosomal ...

The ability to regulate one's own food intake is essential to the survival of both humans and other animals. This innate ability ensures that the body receives the nutrients it needs to perform daily ...

The nervous system is primarily composed of neurons and glia, and the communication between them has profound roles in regulating the development and function of the brain. Neuron–glia signal ...

As knowledge of the development of neuronal pathways continues to grow, it also elucidates potential treatment modalities for neuronal degenerative diseases and injuries. Molecular and genetic ...

A new study found that fructose and glucose may look the same on a nutrition label, but the brain treats them very differently. In mice, glucose strongly reduced activity in hunger-promoting brain ...

Overview of the study. Researchers investigated the neural basis of how animals adapt to new environments and situations. To do this, they introduced a chemical ON/OFF switch in the orbitofrontal ...