A new study shows how the single-molecule organization of receptors in a cellular context determines the function of antibodies, opening up new pathways for the development of cancer immunotherapies.

Deleting a single amino acid (Pro230) in the lower hinge produced half-IgG1 molecules with disrupted disulfide bonds and reoriented Fab and Fc regions, highlighting the hinge’s essential role in ...

A new lipid nanoparticle platform delivers full-length antibodies inside cells, unlocking intracellular targets in cancer, ...

The lower hinge of immunoglobulin G (IgG), an overlooked part of the antibody, acts as a structural and functional control hub, according to a study by researchers at Science Tokyo. Deleting a single ...

A new study shows how the single-molecule organization of receptors in a cellular context determines the function of antibodies, opening up new pathways for the development of cancer immunotherapies.

MOG antibody-associated disease (MOGAD) is a rare autoimmune disease of the central nervous system. The blood of patients contains antibodies against myelin oligodendrocyte glycoprotein (MOG), a ...

The lower hinge of immunoglobulin G (IgG), an overlooked part of the antibody, acts as a structural and functional control hub, according to a study by researchers at Science Tokyo. Deleting a single ...

Antibodies—proteins that are produced by our immune system to protect us—are crucial for recognizing and getting rid of unwanted substances, or antigens, in our body. Although their role is universal, ...

In a recent study posted to the bioRxiv* preprint server, researchers explored the differences in infant and maternal cord antibody functions between severe acute respiratory syndrome coronavirus 2 ...

Researchers have analyzed the antibody Immunoglobulin M in rainbow trout to shed some light on why these proteins may have evolved over time. Antibodies -- proteins that are produced by our immune ...