Cancer cells often survive treatment by fixing the DNA damage that therapy is meant to cause. Researchers found that UNI418 ...

DNA polymerase theta (Pol θ) orchestrates a distinct, error-prone route of double-strand break (DSB) repair known as microhomology-mediated end joining (MMEJ) or theta-mediated end joining (TMEJ).

Newborn nerve cells must squeeze through crowded, narrow spaces—through dense tissue, past other cells, and between fibers—to ...

The Fanconi anaemia pathway is a multi-component DNA damage response system devoted to the recognition and repair of DNA interstrand crosslinks (ICLs) that impede replication and transcription.

"The DNA inside our cells is constantly experiencing damage, and DNA repair is happening all the time to fix that damage and keep our cells healthy. Now, however, it seems these repair processes can ...

A new study in fruit flies describes how an animal's gut reacts differently to beneficial microbes versus harmful pathogens. A pathway known for repairing damaged genetic material, called the ...

Outcomes of nephrectomy in patients with pathologic complete response to immune checkpoint inhibitor therapy for renal cell carcinoma: A multicenter study. Sarcomatoid versus rhabdoid ...

Scientists have discovered that a gene normally considered a DNA-protecting "good guy" can become dangerous when cells make too much of it. The gene, EXO1, acts like molecular scissors that help ...

Similar to the way DNA damage can contribute to human diseases such as cancer, it can also disrupt growth, development and ...

Despite the significance of immune checkpoint inhibitors (ICIs) in solid tumor treatment, identifying ICI-sensitive populations remains a challenge. Mutations in DNA damage response (DDR) pathway ...

Migrating newborn neurons suffer routine double-strand DNA breaks from physical stress during brain development.