A seed reactivates its genome to germinate. By creating a single-cell atlas of germinating embryos, we show that gene expression is highly dynamic and cell specific. Most cells adopt a single, common ...

Plant meristems are specialised tissues at the tips of shoots and roots that harbour pluripotent stem cells responsible for post-embryonic organogenesis. In the shoot apical meristem (SAM), a balance ...

A study published in Cell Research advances a central idea in stem cell biology by identifying a checkpoint that controls the identity of many different types of stem cells across developmental stages ...

Conventional studies on stem cell fates are primarily focused on transcription factors, with the limited consideration for 3D genome architecture. The cohesin complex dynamically restructures ...

Knoepfler is professor of cell biology and human anatomy at UC Davis School of Medicine. Welcome to Lab Dish, a new First Opinion column on regenerative medicine from Paul Knoepfler. Health and Human ...

Scientists have discovered a new protective communication circuit between specialized immune cells in the intestines, a circuit that may be therapeutically targeted to improve inflammatory bowel ...