CSHL’s Krainer lab used a technique called live-cell fluorescence imaging to observe the DDX23 enzyme (above, in green) in action. Together with the critical regulator protein SRSF1, DDX23 helps set ...

Spatial transcriptomics has advanced the study of gene expression in tissues, but most current approaches rely on 3′-end sequencing and provide limited information on alternative splicing (AS).

The modulation of RNA splicing by small molecules has emerged as a promising strategy for treating pathogenic infections, human genetic diseases, and cancer; however, the principles by which splicing ...

RNA splicing is a cellular process that is critical for gene expression. After genes are copied from DNA into messenger RNA, portions of the RNA that don't code for proteins, called introns, are cut ...

The nucleus of each of your cells contains all the genetic information (the genome) necessary to build every type of cell and protein in your entire body. Like a complex library in a tiny space 50 ...

Accurate RNA splicing is essential for gene expression and human health, yet predicting how DNA sequence variations affect splicing remains a major challenge. Although recent artificial intelligence ...

Alzheimer's Disease (AD), the leading cause of dementia, affects nearly 40 million individuals globally, resulting in a gradual loss of memory and independence. Despite extensive research over the ...